An intellectual media outlet for those who embrace the idea of "making health a strategy."

THE AGELESS MAN

THE AGELESS MAN / Episode 12 – Can the brain be rejuvenated?

Where does aging begin?

Is it the face?
Muscles, huh?
Blood vessels, perhaps?

different.

I think.

It's the brain.

I heard this from a brilliant neurosurgeon who graduated from the University of California.

He said he once conducted an experiment where he swapped the brains of young mice with those of older mice.

As a result, the youthfulness of the body was completely replaced.
In other words, an aged body transplanted with a young brain quickly became younger, while a young body transplanted with an elderly brain aged instantly.

The results of that experiment prove it.

When I wake up in the morning
I'm already tired.

I haven't done anything
I feel sluggish.

I know what I need to do.

But

I'm not feeling motivated.

It was different when I was younger.

Let's just do it.
Act without thinking too deeply.
I can do reckless things.

How about now?
First, think.

and
stop.

People
"I've grown up."
That's what they say.

different.

It's just that my brain has aged.

What is brain aging?

Memory loss?
Loss of concentration?

That's also true.

But the essence is different.

It's a decline in motivation.

I'm not feeling motivated.
I don't want to move.
It's a hassle.

This

This is the most dangerous form of aging.

I was that day
I was completely defeated.

My whole body feels heavy.

No, that's not right.

I want to blend in with the ground.
I want to sink like mud.

The corners of the eyes droop.
The corners of the mouth droop.

...I don't want to do anything.

This
It's mental fatigue.

Dr. Tsukada says:
"Your brain is deteriorating."

The one chosen at that time was

A drip of chili oil.
Fucoxanthinol.

Orange.

It's definitely chili oil.

But the contents are
A mass of inflammation control.

Suppresses inflammation within blood vessels
Blocking aging signals
Potential to promote apoptosis in cancer stem cells.

It's a new weapon.

In other words

Eliminate the noise in your brain.

And one more thing.

NMN inhalation.

NMN.

Harbor
David Sinclair

And the University of Washington
Shinichiro Imai

They proved it.
The key to rejuvenation.

But
I honestly thought so.

Is this even working?

I was taking supplements.

But
I don't know.
Hypnosis won't work on me, a skeptical person.
(He's quick to fall under hypnosis when it comes to turning into a baby in front of a beautiful woman.)

The placebo effect doesn't work on me.

The reason is obvious.

There isn't enough.

Mouse experiment
300 mg/kg

Human equivalent
Approximately 1600mg/day

Most commercially available supplements contain around 300mg?

That's ridiculous.

So, an IV drip?

That's also wrong.

The IV drip is fast.

But

It flows away and ends.

Here's a paper.

NMN

In the hypothalamus
A very small dose. And only once.

result

It is more effective than continuous administration.

In other words

Make it work on your brain.

Start inhalation.

My throat is a little sore.

To be honest, it doesn't feel good.

20 minutes.

And then...it ends.

The next moment...it changes.

The fatigue disappears.
The fatigue disappears.
The drowsiness disappears.

My mind is clear.

Fucoxanthinol



back

Remove all weight.

And I

I will become the strongest.

My thoughts are racing.

work
finance
organization
strategy

And for some reason

Strait of Hormuz
globalism
New World Order

You're overthinking it.

But

I can say that with certainty.

My brain has returned.

And then I realize.

Motivation

It directly affects appetite.

in the end

What is youth?

Is it the skin?
Muscle?
Is it a blood vessel?

different.

It's the brain.

If your brain is young
People take action.

If you move
Life goes round and round.

If you stop
To grow old.

I got it back.

AGELESS NOTE

What is brain aging?

Brain aging is
This is not simply a case of memory loss.

• Decreased motivation
• Dopamine deficiency
• Hypothalamic dysfunction
• Chronic inflammation

When these things happen in combination...
This creates a state of being unable to move.

NMN is

via NAD+
• Mitochondrial activity
• Neurological function
• Hypothalamic control

To be involved.

What is important is

Where should the effect be applied?

and

To reduce inflammation.


Next Episode

Ageless Man, Defeated by Loneliness

My body is in good condition.
His brain has recovered.

But

Only one

There were some things that simply couldn't be helped.

Loneliness.
it is

The quietest
The strongest aging factor.

next time
Loneliness is our greatest enemy.

*The treatments described in this blog were determined based on the diagnosis of multiple specialist physicians, not on the patient's own wishes, taking into account the patient's BMI of 27, blood pressure of 180/120, fatty liver, pre-diabetes, metabolic syndrome, and chronic generalized pain.

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山ノ内 辰二

Shinji Yamanouchi

AGELESS Editor-in-Chief / 5Star Medical Club CEO

Age is just a number. It's not a limit. Medicine is moving beyond simply curing diseases. The next challenge for humanity is the end of aging itself. Infectious diseases, cardiovascular diseases, cancer. Humanity has fought against "causes of death" until now. But from now on, it will be an era of challenging the "root cause that produces causes of death." That is aging. A future where organs are created from iPS cells, a future where consciousness is transferred to another body. These will eventually become reality. But I am betting not on a dream 50 years from now, but on a revolution that can be started this very moment. Aging is not time. It is the "order to age" that cells receive. If we can block that order—aging will not be fate, but a choice. I call this idea Biohacking. "All living things must grow old"—that's not science. It's a misconception. In nature, there are organisms that do not age. There are organisms that actually exist that begin to rejuvenate at a certain age and continue to live by repeating aging and regeneration. There is no reason why humanity should be the exception. Human evolution no longer occurs in terms of tens of thousands of years; it occurs in terms of half-century intervals. We have already expanded our physical capabilities. We operate cars as if they were extensions of our own bodies, use AI, and integrate with technology. So now it is time to upgrade biology itself. I conceived the AGELESS program for those who reject the common program of aging, and established the "5 Star Medical Club," which provides information on advanced medical treatments and member support based on requests from affiliated medical institutions. The 5 Star Medical Club is not a medical institution itself, but a membership club that, at the request of each affiliated clinic, provides health management support for members, coordinates medical appointments, and offers accompanying support by medical case workers. The final decision regarding medical treatment and diagnosis is the responsibility of each medical institution. In the AGELESS web magazine, I will be sharing cutting-edge academia, innovative medicine, and my own process of rebelling against aging as an AGELESS MAN. This is not science fiction. This is not the future. The revolution has already begun.

  1. THE AGELESS MAN / Episode 16 – The Project's Current Status – A Look Back at Episodes 6 through 15

  2. THE AGELESS MAN / Episode 15 – iPS Cells: A Time Machine

  3. THE AGELESS MAN / Episode 14 – Kevin Costner and Al Pacino, both are correct, right?

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